Fight Bacteria and Control Blood Sugar with Goldenseal. An expert opinion.

By Staci Gulbin, MS, MEd, RD

Goldenseal, a plant native to North America, has historically been used as a treatment for skin disorders, ulcers, and fevers for many years. Most recently, people use goldenseal to treat colds, respiratory infections, and digestive issues like constipation and diarrhea. This plant-based treatment can help fight bacteria in the body and potentially boost gut and immune system health although more scientific evidence is needed to prove the latter. Read below to learn more about goldenseal and the best goldenseal products online today.

The active ingredient in goldenseal is natural berberine and is the compound known to fight bacteria in the body. Berberine supplement may also help those who are type 2 diabetic control their blood sugar levels as well as it may be Experts suggest that berberine may also be useful for those with heart failure in fighting inflammation.

Most Potent Supplement

Toniiq Ultra High Strength Berberine HCl

This supplement contains a potent formula of berberine extract where many goldenseal health benefits lie. The concentrated formula of this supplement claims to help support blood sugar levels and maintain healthy metabolism.

Summary of Toniiq Ultra High Strength Berberine HCl:
  • Contains 97% berberine HPLC, which is more than most 70% of the products on the market
  • One capsule is equal to the berberine content of 82 raw berberine powder capsules
  • Wild harvested from the resilient Berberis Aristata plants in the foothills of the Himalayas
  • Produced in a GMP-certified and National Sanitation Foundation (NSF)-approved facility to ensure safety, purity, and potency
  • Vegan-friendly
  • No added preservatives
  • Free of wheat and gluten
  • Non-GMO

Most Comprehensive Product

Teraputics IntestinePro Intestine Support

This supplement contains goldenseal and 17 other premium ingredients that can help support intestinal health. This complex of compounds provides a potent formula to help you feel your best inside and out.

Summary of Teraputics IntestinePro Intestine Support:
  • 18 premium ingredients including 5% goldenseal root extract
  • Non-GMO
  • Vegetarian-friendly
  • Contains 45-percent of the daily recommended value of the antioxidant zinc
  • One capsule taken three times daily
  • Formulated in the United States
  • Sourced from a Good Manufacturing Practices (GMP), FDA-registered facility that ensures product potency and purity
  • Third-party certified

Best Berberine HCl Supplement

EzyAbsorb Gluten-Free Berberine

This berberine supplement contain berberine HCl which is thought to absorb well in the body. Better absorption may in turn help you to reap the health benefits of berberine such as blood sugar support and infection prevention.

Summary of EzyAbsorb Gluten-Free Berberine:
  • Contains Berberine HCl, which is more easily absorbed into the blood stream
  • Produced in a GMP-certified and NSF-approved facility to ensure safety, purity, and potency
  • One capsule three times daily to provide 1500 milligrams berberine
  • Third-party tested
  • Made in the United States
  • No fillers, binders, or artificial ingredients
  • Certified vegan-friendly
  • Free of common allergens like shellfish, eggs, fish, peanuts, milk, soy, and tree nuts
  • 100% natural organic

What You Need to Know


Goldenseal is found in capsules, tablets, extracts, and teas for intake. The roots and rhizome, or underground stem is the part you find in goldenseal supplements.

The typical dosage of goldenseal depends on the form of the plant you consume. For example, for dried tea, you should consume 0.5 to 1 gram three times daily for best results. However, for a liquid goldenseal root extract that is 1:1 and 60% ethanol, you should consume 0.3 grams to 1 gram three times daily.


More studies are needed to confirm the benefits of goldenseal, or hydrastis canadensis. However, there are some studies that do show the aerial portions of this plant, or those parts exposed to air, to have antibacterial and anti-inflammatory properties. For example, goldenseal extract may help prevent infection and cell damage by methicillin-resistant Staphylococcus aureus (MRSA) bacteria.

Also, there is a 2017 study that looked at the effect of the flavonoids in goldenseal leaves that can enhance its antibacterial properties. Study results show three flavonoids called sideroxylin, 6-desmethyl sideroxylin, and 8-desmethyl sideroxylin,enhance the antimicrobial benefits of goldenseal.


In some people, you may have side effects after taking goldenseal like:

  • Constipation
  • Delirium
  • Irritation of the mouth or throat
  • Skin irritation

If you consume too much goldenseal, you may have overdose symptoms such as the following:

  • Cardiac damage
  • Depression
  • Nausea
  • Vomiting
  • Low blood pressure
  • Nervousness
  • Respiratory failure
  • Shortness of breath
  • Spasms
  • Slow heart rate

If you have any of the above symptoms after taking goldenseal, be sure to seek medical advice and attention right away. Also, those who are pregnant, breastfeeding, have inflammatory digestive issues, have high levels of bilirubin in the blood, or children should not take goldenseal.

And although goldenseal is not known to have any drug interactions, berberine is known to interact with medicines like cyclosporine, robitussin, antidiabetes drugs, losartan, blood pressure drugs, blood clotting drugs, some anesthesia drugs, and sedatives. Therefore, be sure to check with your doctor before taking any new supplement. For those people with such issues such as inflammatory conditions, read this article for other natural ways to fight inflammation and boost gut health.

Anything else a shopper should know to make a decision

Just like when choosing any herbal supplements, be sure that the supplement you choose has been tested by a third-party to ensure potency and purity which will help you know if what you see on the label, as far as compounds and amounts of each compound, is what you are buying. Also, be sure to check for any added compounds that you may be allergic or sensitive to so you can ensure your safety.

Our Remedy Review

Why Would You Take Goldenseal?

You would take goldenseal if you are prone to infections or viruses. It may be helpful to take as cold and flu season approaches to help lower your risk of getting sick.

Is it worth your money?

If goldenseal helps to lower your risk of getting sick, then it could help reduce the number of sick days you may have to take off from work. Therefore, it will save you money in the regard and would be worth the price you pay for the supplement.

Who is best for?

Goldenseal supplements are best for adults who are prone to sickness and do not have any pre-existing gut health issues. It’s important to check with your healthcare provider before starting this supplement to see if it could help you improve your immune health.

By continuing to browse or by clicking “OK” you agree to the storing of first- and third-party cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Privacy Policy.