The Best Melatonin Supplements

By Jeremy Campbell

A good night’s sleep is essential for good mental and physical health, but for some, falling asleep and staying asleep can be difficult.

Many people resort to prescription sleep aids which often come with unwanted side effects. For those seeking a natural alternative, melatonin supplements may offer an effective remedy.

Best Overall Melatonin Supplement

Puritan’s Pride Super Strength Melatonin

Puritan’s Pride is known for providing top quality products. They produce over 1,200 vitamins, minerals, and other various supplements and require all their suppliers to meet stringent quality standards.

Puritan’s Pride Super Strength Rapid Release Melatonin is ranked Number 1 under Labdoor’s Melatonin category, receiving high marks for label accuracy and ingredient safety. 

It contains 10 mg of melatonin per dose, which is more per dosage than most brands thus it’s great for those who’ve tried low strength melatonin supplements and found them to be ineffective. Also, it includes rapid release technology to put people to sleep faster than other products.

Summary of Puritan’s Pride Super Strength Melatonin:
  • High dosage of melatonin per serving
  • Rapid Release Technology for faster absorption
  • No artificial flavorings, sweeteners, colors, preservatives, sugars, starches
  • Allergen-free: no milk, soy, gluten, wheat, yeast or fish

Best Melatonin Supplement for Children

Zarbee’s Naturals Children’s Sleep with Melatonin

Zarbee’s was founded by famed pediatrician Dr. Zak Zarbock and they specialize in producing chemical-free products, suitable for use in both children and adults. They’re committed to having few but quality ingredients.

Zarbee’s Naturals Children’s Sleep with Melatonin is a great low-dose melatonin supplement for children who have trouble taking melatonin in pill form. These chewable tablets come in fruity flavors that are kid-friendly.

This non-habit-forming natural sleep aid is effective in promoting restful sleep by working with the body’s natural sleep cycle. While other sleep aids may result in day-time drowsiness, low-dose melatonin is effective at inducing quality sleep with no lingering side effects the next morning.

Summary of Zarbee’s Naturals Children’s Sleep with Melatonin:
  • No artificial sweeteners, artificial flavors, dyes, drugs, alcohol, or gluten
  • Low dosage of melatonin at just 1mg, thus suitable for both children and adults
  • Chewy gummies easy to ingest for those who have trouble swallowing pills

Best Melatonin Alternative

Dee Cee Labs Formula 303 Natural Relaxant

If you’re looking for a melatonin alternative, look no further than Dee Cee Labs Formula 303 Maximum Strength Natural Relaxant Tablets featuring all-natural Valerian Root, Passiflora, and Magnesium Carbonate. These herbs and minerals work differently than melatonin to promote better and more consistent sleep.

Additionally, Dee Cee Labs focus on producing supplements with an eye on sustainable, green practices. An example of their stand-out efforts to be environmentally-conscious was to install one of the largest solar panel systems in the state of Tennessee which produces enough energy to run both their entire manufacturing facility and office complex.

Instead of using melatonin, Formula 303 includes:
  • Valerian Root: Valerian Root has been used since ancient times to help people relax and is known to provide better sleep.
  • Passiflora: Passiflora has been to help with anxiety and insomnia.
  • Magnesium Carbonate: Magnesium is known to activate neurotransmitters which help to calm the mind and body while not getting enough magnesium can result in a variety of sleep issues.

In using these ingredients, Formula 303 can impact more than sleep, but it can also be effective at providing relief for muscle pain, nervousness, fibromyalgia, or restless legs syndrome.

Note: This product doesn’t contain melatonin, thus if you’re looking for a natural sleep aid that does, consider another supplement.

What You Need to Know

Natural vs Synthetic Melatonin

You’ll find products with naturally or synthetically made melatonin. For vegans or vegetarians, look for a synthetic melatonin supplement as natural melatonin supplements are sourced from the pineal glands of animals.

Benefits of Melatonin

There are a variety of benefits to supplementing melatonin. Here are a few:

Potential Side Effects

Potential side effects of melatonin supplementation include:

  • Drowsiness
  • Depression
  • Headache
  • Nausea


While melatonin is generally considered a safe supplement, there are still a few important things to keep in mind before giving it a try.

For starters, melatonin is a hormone, and as with any hormone, too much can cause an imbalance in the body. For example, women with high levels of melatonin can run into issues with their reproductive hormones while in men, prolonged use of melatonin may result in a reduction in sperm motility.

Melatonin may also interact negatively with some medications, such as:

  • Immune system suppressors
  • Diabetes medications
  • Anticonvulsants
  • Contraceptives
  • Blood thinners

What does melatonin do?

Melatonin is also known as the “darkness hormone” because it is produced when our eyes experience darkness and can be affected by even the smallest amount of light. Though light suppresses melatonin, it increases cortisol, a stress hormone that tells us to wake up and stay alert. Cortisol and melatonin work against each other for our benefit. We want melatonin to be high to put us asleep and low when we are awake, and cortisol to be low when we are asleep and high to wake us up and to keep us awake. Additionally, serotonin is a neurotransmitter and a precursor to melatonin and it takes about 12 hours for serotonin to convert to melatonin. If these hormones get out of sync, there are natural remedies you can try like taking a walk in the morning sun for 30-40 minutes, making your room completely dark at night and avoiding blue light emitting screens at least one hour before bed. Luckily, you can also take melatonin as a supplement which is especially useful if you are jetlagged or a shift worker.

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